Drug interactions
Procarbazine + Tisagenlecleucel
Severity: Major
Procarbazine and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a myelosuppressive and immunosuppressive chemotherapy drug that can impair T-cell function and reduce counts. If given around tisagenlecleucel it may reduce CAR-T cell expansion and persistence, and add to infection risk.
What this interaction means in plain words
Procarbazine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Procarbazine belongs to Oncology; Tisagenlecleucel belongs to Oncology.
Why it happens
Pharmacodynamic antagonism through lymphotoxic and immunosuppressive effects on the CAR-T cells, plus additive immunosuppression.
What to do
Avoid giving procarbazine in the period before leukapheresis and after infusion unless clearly needed, following the product labeling for washout. Monitor for infection and blood counts if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Procarbazine with Tisagenlecleucel?
MediHelp rates the interaction as major. Procarbazine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine is a myelosuppressive and immunosuppressive chemotherapy drug that can impair T-cell function and reduce counts. If given around tisagenlecleucel it may reduce CAR-T cell expansion and persistence, and add to infection risk.
How serious is the interaction between Procarbazine and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving procarbazine in the period before leukapheresis and after infusion unless clearly needed, following the product labeling for washout. Monitor for infection and blood counts if it cannot be avoided.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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