Drug interactions
Procarbazine + Trastuzumab
Severity: Moderate
Procarbazine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy such as procarbazine has been associated with more neutropenia and febrile neutropenia. Infection risk may therefore be higher than with chemotherapy alone.
What this interaction means in plain words
Procarbazine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity, with procarbazine causing bone marrow suppression and trastuzumab adding to neutropenia.
What to do
Monitor complete blood counts regularly and watch for fever or infection. Delay or reduce doses and consider growth factor support according to oncology protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Procarbazine with Trastuzumab?
MediHelp rates the interaction as moderate. Procarbazine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy such as procarbazine has been associated with more neutropenia and febrile neutropenia. Infection risk may therefore be higher than with chemotherapy alone.
How serious is the interaction between Procarbazine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection. Delay or reduce doses and consider growth factor support according to oncology protocols.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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