Drug interactions
Progesterone intravaginal + Ribociclib
Severity: Minor
Progesterone intravaginal and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone is metabolized by CYP3A4, but intravaginal gel gives low systemic exposure with a local effect. A clinically meaningful change from ribociclib is unlikely.
What this interaction means in plain words
Progesterone intravaginal and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, which may slightly slow progesterone metabolism.
What to do
No action is needed. Review hormone therapy suitability in breast cancer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Progesterone intravaginal with Ribociclib?
MediHelp rates the interaction as minor. Progesterone intravaginal and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone is metabolized by CYP3A4, but intravaginal gel gives low systemic exposure with a local effect. A clinically meaningful change from ribociclib is unlikely.
How serious is the interaction between Progesterone intravaginal and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed. Review hormone therapy suitability in breast cancer.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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