Drug interactions
Progesterone intravaginal + Voriconazole
Severity: Minor
Progesterone intravaginal and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole could modestly raise systemic progesterone exposure. Vaginal progesterone avoids much first-pass metabolism, so the clinical effect is probably small.
What this interaction means in plain words
Progesterone intravaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of progesterone.
What to do
No routine adjustment is needed. Watch for progestogenic effects such as drowsiness and breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Progesterone intravaginal with Voriconazole?
MediHelp rates the interaction as minor. Progesterone intravaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole could modestly raise systemic progesterone exposure. Vaginal progesterone avoids much first-pass metabolism, so the clinical effect is probably small.
How serious is the interaction between Progesterone intravaginal and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for progestogenic effects such as drowsiness and breast tenderness.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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