Drug interactions
Progesterone micronized + Ribociclib
Severity: Minor
Progesterone micronized and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone undergoes extensive CYP3A4 metabolism, so ribociclib may raise its levels. This could increase sedation and dizziness.
What this interaction means in plain words
Progesterone micronized and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ribociclib inhibits CYP3A4, reducing progesterone first-pass metabolism.
What to do
Monitor for drowsiness and dizziness and lower the progesterone dose if needed. Review hormone therapy suitability in breast cancer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Progesterone micronized with Ribociclib?
MediHelp rates the interaction as minor. Progesterone micronized and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral micronized progesterone undergoes extensive CYP3A4 metabolism, so ribociclib may raise its levels. This could increase sedation and dizziness.
How serious is the interaction between Progesterone micronized and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness and lower the progesterone dose if needed. Review hormone therapy suitability in breast cancer.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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