Drug interactions
Progesterone micronized + Voriconazole
Severity: Moderate
Progesterone micronized and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase exposure to oral micronized progesterone, which undergoes extensive CYP3A4 first-pass metabolism. This can increase sedation, dizziness and other progestogenic effects.
What this interaction means in plain words
Progesterone micronized and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits intestinal and hepatic CYP3A4 metabolism of progesterone.
What to do
Monitor for excess sedation and dizziness, and advise taking progesterone at bedtime. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Progesterone micronized with Voriconazole?
MediHelp rates the interaction as moderate. Progesterone micronized and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase exposure to oral micronized progesterone, which undergoes extensive CYP3A4 first-pass metabolism. This can increase sedation, dizziness and other progestogenic effects.
How serious is the interaction between Progesterone micronized and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, and advise taking progesterone at bedtime. Reduce the dose if adverse effects occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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