Drug interactions
Promethazine + Ramelteon
Severity: Minor
Promethazine and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with the hypnotic ramelteon may increase drowsiness and next-day impairment. The effect is expected to be additive and generally modest.
What this interaction means in plain words
Promethazine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Ramelteon belongs to Central Nervous System.
Why it happens
Additive sedative effects through H1 antagonism and melatonin receptor agonism.
What to do
Warn patients about daytime drowsiness and avoid driving until the response is known. Avoid adding other sedatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Promethazine with Ramelteon?
MediHelp rates the interaction as minor. Promethazine and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a sedating antihistamine with the hypnotic ramelteon may increase drowsiness and next-day impairment. The effect is expected to be additive and generally modest.
How serious is the interaction between Promethazine and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about daytime drowsiness and avoid driving until the response is known. Avoid adding other sedatives.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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