Drug interactions
Promethazine + Saxagliptin-metformin
Severity: Minor
Promethazine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce the effect of antidiabetic drugs. The effect is usually modest but may matter in patients with poor control.
What this interaction means in plain words
Promethazine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism with possible impaired glucose tolerance from phenothiazine effects.
What to do
Monitor blood glucose during prolonged or repeated promethazine use. Adjust antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Promethazine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Promethazine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce the effect of antidiabetic drugs. The effect is usually modest but may matter in patients with poor control.
How serious is the interaction between Promethazine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during prolonged or repeated promethazine use. Adjust antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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