Drug interactions
Promethazine + Sertraline
Severity: Minor
Promethazine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, although sertraline has a low risk, so the combined effect is usually small. Sertraline also inhibits CYP2D6 weakly, which may modestly raise promethazine exposure.
What this interaction means in plain words
Promethazine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Sertraline belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation and weak CYP2D6 inhibition by sertraline.
What to do
No routine action is needed. Check an ECG and electrolytes if other QT-prolonging drugs or cardiac risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Promethazine with Sertraline?
MediHelp rates the interaction as minor. Promethazine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can prolong the QT interval, although sertraline has a low risk, so the combined effect is usually small. Sertraline also inhibits CYP2D6 weakly, which may modestly raise promethazine exposure.
How serious is the interaction between Promethazine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check an ECG and electrolytes if other QT-prolonging drugs or cardiac risk factors are present.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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