Drug interactions
Promethazine + Sparsentan
Severity: Minor
Promethazine and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can induce CYP2B6 and may lower exposure to drugs cleared by that enzyme. Promethazine is metabolised mainly by other pathways, so any reduction in its effect is likely small.
What this interaction means in plain words
Promethazine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2B6, which has at most a minor role in promethazine metabolism.
What to do
No dose change is usually needed. Watch for reduced antihistaminic or antiemetic effect if the response seems diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Promethazine with Sparsentan?
MediHelp rates the interaction as minor. Promethazine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan can induce CYP2B6 and may lower exposure to drugs cleared by that enzyme. Promethazine is metabolised mainly by other pathways, so any reduction in its effect is likely small.
How serious is the interaction between Promethazine and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for reduced antihistaminic or antiemetic effect if the response seems diminished.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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