Drug interactions
Propafenone + Tolterodine
Severity: Moderate
Propafenone and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits CYP2D6 and can increase tolterodine concentrations, and both agents have QT-prolonging potential. This increases anticholinergic effects and arrhythmia risk.
What this interaction means in plain words
Propafenone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Tolterodine belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by propafenone reduces tolterodine clearance, with additive QT effects.
What to do
Monitor for anticholinergic effects and the QTc on an ECG. Reduce the tolterodine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Tolterodine?
MediHelp rates the interaction as moderate. Propafenone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits CYP2D6 and can increase tolterodine concentrations, and both agents have QT-prolonging potential. This increases anticholinergic effects and arrhythmia risk.
How serious is the interaction between Propafenone and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and the QTc on an ECG. Reduce the tolterodine dose if adverse effects appear.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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