Drug interactions
Propafenone + Vandetanib
Severity: Contraindicated
Propafenone and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked QT prolongation, with reports of torsades de pointes and sudden death. Its labeling advises against using it with other QT-prolonging drugs, and propafenone adds proarrhythmic effects.
What this interaction means in plain words
Propafenone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Propafenone belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation and proarrhythmic effects.
What to do
Do not combine; use a different antiarrhythmic while on vandetanib. If a QT-prolonging drug is unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Propafenone with Vandetanib?
MediHelp rates the interaction as contraindicated. Propafenone and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked QT prolongation, with reports of torsades de pointes and sudden death. Its labeling advises against using it with other QT-prolonging drugs, and propafenone adds proarrhythmic effects.
How serious is the interaction between Propafenone and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a different antiarrhythmic while on vandetanib. If a QT-prolonging drug is unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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