Drug interactions
Propranolol + Riociguat
Severity: Moderate
Propranolol and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so the combination may cause additive hypotension. Propranolol is not a strong CYP inhibitor, so a large pharmacokinetic effect on riociguat is not expected.
What this interaction means in plain words
Propranolol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; propranolol is not a strong inhibitor of riociguat metabolism.
What to do
Monitor blood pressure and symptoms of hypotension, especially at riociguat initiation and titration. Reduce the riociguat dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Propranolol with Riociguat?
MediHelp rates the interaction as moderate. Propranolol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so the combination may cause additive hypotension. Propranolol is not a strong CYP inhibitor, so a large pharmacokinetic effect on riociguat is not expected.
How serious is the interaction between Propranolol and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension, especially at riociguat initiation and titration. Reduce the riociguat dose if symptomatic hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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