Drug interactions
Propranolol + Sertraline
Severity: Minor
Propranolol and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline weakly to moderately inhibits CYP2D6 and may modestly raise propranolol levels. This can produce additional bradycardia or hypotension, but the effect is usually small.
What this interaction means in plain words
Propranolol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline inhibits CYP2D6-mediated propranolol metabolism.
What to do
Monitor heart rate and blood pressure after starting or changing sertraline dose. Reduce the propranolol dose only if bradycardia or hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Propranolol with Sertraline?
MediHelp rates the interaction as minor. Propranolol and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline weakly to moderately inhibits CYP2D6 and may modestly raise propranolol levels. This can produce additional bradycardia or hypotension, but the effect is usually small.
How serious is the interaction between Propranolol and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting or changing sertraline dose. Reduce the propranolol dose only if bradycardia or hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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