Drug interactions
Propranolol + Tolfenamic acid
Severity: Moderate
Propranolol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers with prolonged use, leading to higher blood pressure. They may also impair renal function and cause fluid retention.
What this interaction means in plain words
Propranolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduces vasodilation.
What to do
Monitor blood pressure when NSAIDs are used for more than a few days, and use the lowest effective NSAID dose for the shortest time. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Propranolol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Propranolol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers with prolonged use, leading to higher blood pressure. They may also impair renal function and cause fluid retention.
How serious is the interaction between Propranolol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAIDs are used for more than a few days, and use the lowest effective NSAID dose for the shortest time. Consider paracetamol as an alternative.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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