Drug interactions
Propranolol + Umeclidinium-vilanterol
Severity: Major
Propranolol and Umeclidinium-vilanterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and opposes the bronchodilating action of vilanterol. This can cause bronchospasm and reduced inhaler effectiveness, particularly in patients with COPD or asthma.
What this interaction means in plain words
Propranolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propranolol belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a non-selective beta-blocker.
What to do
Avoid propranolol in patients using this inhaler; if a beta-blocker is essential, choose a cardioselective beta-1 agent at the lowest effective dose. Monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propranolol and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Umeclidinium-vilanterol
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Propranolol and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta-blocker that blocks beta-2 receptors in the airways and opposes the bronchodilating action of vilanterol. This can cause bronchospasm and reduced inhaler effectiveness, particularly in patients with COPD or asthma.
How serious is the interaction between Propranolol and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid propranolol in patients using this inhaler; if a beta-blocker is essential, choose a cardioselective beta-1 agent at the lowest effective dose. Monitor respiratory symptoms and lung function.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
