Drug interactions
Propranolol + Venetoclax
Severity: Moderate
Propranolol and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol may inhibit P-glycoprotein and raise venetoclax exposure. Higher venetoclax levels could increase toxicities such as neutropenia and, in initiation phases, tumor lysis syndrome. The inhibitory effect of propranolol on P-gp is weak and poorly characterized.
What this interaction means in plain words
Propranolol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Possible inhibition of P-glycoprotein efflux of venetoclax, increasing its absorption and systemic exposure.
What to do
Monitor blood counts and signs of venetoclax toxicity closely, especially during dose ramp-up. Consider a beta-blocker that is not a P-gp inhibitor if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Propranolol with Venetoclax?
MediHelp rates the interaction as moderate. Propranolol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol may inhibit P-glycoprotein and raise venetoclax exposure. Higher venetoclax levels could increase toxicities such as neutropenia and, in initiation phases, tumor lysis syndrome. The inhibitory effect of propranolol on P-gp is weak and poorly characterized.
How serious is the interaction between Propranolol and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of venetoclax toxicity closely, especially during dose ramp-up. Consider a beta-blocker that is not a P-gp inhibitor if toxicity emerges.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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