Drug interactions
Propylthiouracil + Ropeginterferon alfa 2b
Severity: Moderate
Propylthiouracil and Ropeginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can suppress bone marrow, and propylthiouracil may cause agranulocytosis. Together they may produce additive neutropenia and other cytopenias with infection risk.
What this interaction means in plain words
Propylthiouracil and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts with differential regularly, and counsel the patient to report fever or sore throat promptly; reduce or stop a drug for significant cytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propylthiouracil
Frequently asked questions
Can I take Propylthiouracil with Ropeginterferon alfa 2b?
MediHelp rates the interaction as moderate. Propylthiouracil and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can suppress bone marrow, and propylthiouracil may cause agranulocytosis. Together they may produce additive neutropenia and other cytopenias with infection risk.
How serious is the interaction between Propylthiouracil and Ropeginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts with differential regularly, and counsel the patient to report fever or sore throat promptly; reduce or stop a drug for significant cytopenia.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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