Drug interactions
Protein c concentrate + Rivaroxaban
Severity: Moderate
Protein c concentrate and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protein C concentrate has anticoagulant activity by inactivating factors Va and VIIIa. Added to rivaroxaban, it may increase bleeding risk.
What this interaction means in plain words
Protein c concentrate and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticoagulant effects through different coagulation pathways.
What to do
Monitor for bleeding and consider temporarily adjusting or holding rivaroxaban during replacement therapy. Check coagulation parameters as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Protein c concentrate with Rivaroxaban?
MediHelp rates the interaction as moderate. Protein c concentrate and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protein C concentrate has anticoagulant activity by inactivating factors Va and VIIIa. Added to rivaroxaban, it may increase bleeding risk.
How serious is the interaction between Protein c concentrate and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider temporarily adjusting or holding rivaroxaban during replacement therapy. Check coagulation parameters as clinically indicated.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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