Drug interactions
Prothrombin complex concentrate human + Rivaroxaban
Severity: Major
Prothrombin complex concentrate human and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prothrombin complex concentrate is used off-label or per local protocol to reverse rivaroxaban, so it directly opposes the anticoagulant effect. It carries thrombotic risk, so it should be reserved for serious bleeding.
What this interaction means in plain words
Prothrombin complex concentrate human and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism: replacement of clotting factors overcomes factor Xa inhibition, with prothrombotic potential.
What to do
Use only for life-threatening bleeding or urgent surgery, and watch for thromboembolic events. Consider andexanet alfa where available; restart anticoagulation when safe.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Prothrombin complex concentrate human with Rivaroxaban?
MediHelp rates the interaction as major. Prothrombin complex concentrate human and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prothrombin complex concentrate is used off-label or per local protocol to reverse rivaroxaban, so it directly opposes the anticoagulant effect. It carries thrombotic risk, so it should be reserved for serious bleeding.
How serious is the interaction between Prothrombin complex concentrate human and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only for life-threatening bleeding or urgent surgery, and watch for thromboembolic events. Consider andexanet alfa where available; restart anticoagulation when safe.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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