Drug interactions
Prothrombin complex concentrate human + Tranexamic acid
Severity: Major
Prothrombin complex concentrate human and Tranexamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prothrombin complex concentrate supplies vitamin K-dependent clotting factors and tranexamic acid prevents clot breakdown. Together they may increase the risk of thromboembolic events.
What this interaction means in plain words
Prothrombin complex concentrate human and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prothrombotic effect from clotting factor replacement and antifibrinolytic inhibition of clot breakdown.
What to do
Use together only when clearly indicated, with careful thrombosis monitoring. Avoid routine co-administration and use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
Frequently asked questions
Can I take Prothrombin complex concentrate human with Tranexamic acid?
MediHelp rates the interaction as major. Prothrombin complex concentrate human and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prothrombin complex concentrate supplies vitamin K-dependent clotting factors and tranexamic acid prevents clot breakdown. Together they may increase the risk of thromboembolic events.
How serious is the interaction between Prothrombin complex concentrate human and Tranexamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly indicated, with careful thrombosis monitoring. Avoid routine co-administration and use the lowest effective doses.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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