Drug interactions
Protriptyline + Solifenacin
Severity: Major
Protriptyline and Solifenacin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a strongly anticholinergic tricyclic antidepressant, and combining it with solifenacin increases risks of urinary retention, constipation, dry mouth, confusion and tachycardia. Both can also prolong the QT interval, adding to cardiac risk.
What this interaction means in plain words
Protriptyline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Avoid the combination in older or cognitively impaired patients and consider alternatives. If used, monitor ECG/QTc and anticholinergic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Protriptyline and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Solifenacin 10 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: anticholinergic properties; "Concomitant medication with other medicinal products with anticholinergic properties may result in more pronounced therapeutic effects and undesirable effects.") — electronic medicines compendium (UK SmPC)
Other interactions of Solifenacin
Frequently asked questions
Can I take Protriptyline with Solifenacin?
MediHelp rates the interaction as major. Protriptyline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Protriptyline is a strongly anticholinergic tricyclic antidepressant, and combining it with solifenacin increases risks of urinary retention, constipation, dry mouth, confusion and tachycardia. Both can also prolong the QT interval, adding to cardiac risk.
How serious is the interaction between Protriptyline and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older or cognitively impaired patients and consider alternatives. If used, monitor ECG/QTc and anticholinergic symptoms.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
