Drug interactions
Protriptyline + Zolmitriptan
Severity: Moderate
Protriptyline and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline blocks serotonin and norepinephrine reuptake, so with zolmitriptan it may rarely cause serotonin syndrome.
What this interaction means in plain words
Protriptyline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity through reuptake inhibition and 5-HT1 agonism.
What to do
Counsel on symptoms and monitor after starting or changing doses. Discontinue the agents and give supportive care if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Protriptyline and Zolmitriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Protriptyline with Zolmitriptan?
MediHelp rates the interaction as moderate. Protriptyline and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline blocks serotonin and norepinephrine reuptake, so with zolmitriptan it may rarely cause serotonin syndrome.
How serious is the interaction between Protriptyline and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms and monitor after starting or changing doses. Discontinue the agents and give supportive care if serotonin syndrome occurs.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
