Drug interactions
Quazepam + Ribociclib
Severity: Moderate
Quazepam and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is metabolized by CYP3A4 and other enzymes, so ribociclib may increase its exposure. This can intensify sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Quazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, decreasing quazepam clearance.
What to do
Monitor for excessive sedation and consider a lower quazepam dose while ribociclib is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Quazepam with Ribociclib?
MediHelp rates the interaction as moderate. Quazepam and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is metabolized by CYP3A4 and other enzymes, so ribociclib may increase its exposure. This can intensify sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Quazepam and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower quazepam dose while ribociclib is given.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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