Drug interactions
Quazepam + Tapentadol
Severity: Major
Quazepam and Tapentadol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids given with benzodiazepines can cause profound sedation, respiratory depression, coma and death. This is a labeled warning for the opioid class.
What this interaction means in plain words
Quazepam and Tapentadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid receptor and GABA-A receptor activity.
What to do
Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor for respiratory depression and sedation, and counsel patients and carers about the risks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Frequently asked questions
Can I take Quazepam with Tapentadol?
MediHelp rates the interaction as major. Quazepam and Tapentadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids given with benzodiazepines can cause profound sedation, respiratory depression, coma and death. This is a labeled warning for the opioid class.
How serious is the interaction between Quazepam and Tapentadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor for respiratory depression and sedation, and counsel patients and carers about the risks.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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