Drug interactions
Quazepam + Voriconazole
Severity: Moderate
Quazepam and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase quazepam exposure and prolong its effects. This can cause excess sedation, psychomotor impairment and respiratory depression, particularly in older adults.
What this interaction means in plain words
Quazepam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 (and CYP2C19), reducing quazepam clearance.
What to do
Use a reduced quazepam dose and monitor for oversedation. Consider a benzodiazepine cleared by glucuronidation if combined therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Quazepam with Voriconazole?
MediHelp rates the interaction as moderate. Quazepam and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase quazepam exposure and prolong its effects. This can cause excess sedation, psychomotor impairment and respiratory depression, particularly in older adults.
How serious is the interaction between Quazepam and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced quazepam dose and monitor for oversedation. Consider a benzodiazepine cleared by glucuronidation if combined therapy is needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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