Drug interactions
Quercetin + Sirolimus
Severity: Minor
Quercetin and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin is a flavonoid supplement that may alter P-glycoprotein and CYP3A4 activity, potentially changing sirolimus concentrations unpredictably. Data are limited and the clinical effect is uncertain.
What this interaction means in plain words
Quercetin and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of intestinal P-glycoprotein and CYP3A4; the net effect is not well established.
What to do
Advise patients to avoid high-dose quercetin supplements. If they are used, monitor sirolimus trough concentrations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Quercetin with Sirolimus?
MediHelp rates the interaction as minor. Quercetin and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin is a flavonoid supplement that may alter P-glycoprotein and CYP3A4 activity, potentially changing sirolimus concentrations unpredictably. Data are limited and the clinical effect is uncertain.
How serious is the interaction between Quercetin and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid high-dose quercetin supplements. If they are used, monitor sirolimus trough concentrations.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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