Drug interactions
Quercetin + Tacrolimus
Severity: Minor
Quercetin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin is a flavonoid supplement that can modulate intestinal P-glycoprotein and CYP3A. Its effect on tacrolimus exposure is inconsistent and based on limited data, so concentrations could change unpredictably.
What this interaction means in plain words
Quercetin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quercetin may alter P-glycoprotein and CYP3A activity, but the direction and size of the effect on tacrolimus are not firmly established.
What to do
Advise patients to avoid high-dose quercetin supplements, or check tacrolimus troughs after starting or stopping them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Quercetin with Tacrolimus?
MediHelp rates the interaction as minor. Quercetin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin is a flavonoid supplement that can modulate intestinal P-glycoprotein and CYP3A. Its effect on tacrolimus exposure is inconsistent and based on limited data, so concentrations could change unpredictably.
How serious is the interaction between Quercetin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid high-dose quercetin supplements, or check tacrolimus troughs after starting or stopping them.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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