Drug interactions
Quetiapine + Rifabutin
Severity: Moderate
Quetiapine and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4, though less strongly than rifampicin, and can lower quetiapine exposure. Reduced levels may cause loss of psychiatric control.
What this interaction means in plain words
Quetiapine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifabutin increases quetiapine metabolism.
What to do
Monitor clinical response and increase the quetiapine dose if needed. Reduce the dose again when rifabutin is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Quetiapine with Rifabutin?
MediHelp rates the interaction as moderate. Quetiapine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4, though less strongly than rifampicin, and can lower quetiapine exposure. Reduced levels may cause loss of psychiatric control.
How serious is the interaction between Quetiapine and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the quetiapine dose if needed. Reduce the dose again when rifabutin is discontinued.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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