Drug interactions
Quetiapine + Rufinamide
Severity: Minor
Quetiapine and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may modestly lower quetiapine concentrations. The effect is generally small but could reduce antipsychotic efficacy in some patients.
What this interaction means in plain words
Quetiapine and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quetiapine belongs to Central Nervous System; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases quetiapine metabolism.
What to do
Monitor clinical response to quetiapine after starting or stopping rufinamide and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Quetiapine with Rufinamide?
MediHelp rates the interaction as minor. Quetiapine and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may modestly lower quetiapine concentrations. The effect is generally small but could reduce antipsychotic efficacy in some patients.
How serious is the interaction between Quetiapine and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quetiapine after starting or stopping rufinamide and adjust the dose if needed.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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