Drug interactions
Quetiapine + Safinamide
Severity: Moderate
Quetiapine and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks dopamine receptors and can oppose the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen, although quetiapine has less motor effect than other antipsychotics.
What this interaction means in plain words
Quetiapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine D2 blockade and MAO-B inhibitor dopaminergic enhancement.
What to do
Use the lowest effective quetiapine dose and monitor motor function. Quetiapine is generally the preferred antipsychotic in Parkinson disease if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Quetiapine with Safinamide?
MediHelp rates the interaction as moderate. Quetiapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks dopamine receptors and can oppose the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen, although quetiapine has less motor effect than other antipsychotics.
How serious is the interaction between Quetiapine and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quetiapine dose and monitor motor function. Quetiapine is generally the preferred antipsychotic in Parkinson disease if one is needed.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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