Drug interactions
Quetiapine + Scopolamine
Severity: Moderate
Quetiapine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine and its metabolite have anticholinergic activity and cause marked sedation, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion. The risk is highest in elderly patients.
What this interaction means in plain words
Quetiapine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and CNS depression.
What to do
Monitor for sedation, delirium and anticholinergic effects, and keep the scopolamine duration short. Lower the dose or choose an alternative if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Scopolamine?
MediHelp rates the interaction as moderate. Quetiapine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine and its metabolite have anticholinergic activity and cause marked sedation, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion. The risk is highest in elderly patients.
How serious is the interaction between Quetiapine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, delirium and anticholinergic effects, and keep the scopolamine duration short. Lower the dose or choose an alternative if effects emerge.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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