Drug interactions
Quetiapine + Selegiline
Severity: Moderate
Quetiapine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor and dopamine agonist effect may be opposed by quetiapine dopamine blockade, potentially worsening parkinsonian symptoms. Serotonin syndrome is a theoretical concern.
What this interaction means in plain words
Quetiapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of dopaminergic effects, with theoretical additive serotonergic effects.
What to do
Monitor motor symptoms and for signs of serotonin toxicity such as agitation, tremor and hyperthermia. Quetiapine is generally preferred over other antipsychotics in Parkinson disease, at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Quetiapine with Selegiline?
MediHelp rates the interaction as moderate. Quetiapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO-B inhibitor and dopamine agonist effect may be opposed by quetiapine dopamine blockade, potentially worsening parkinsonian symptoms. Serotonin syndrome is a theoretical concern.
How serious is the interaction between Quetiapine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and for signs of serotonin toxicity such as agitation, tremor and hyperthermia. Quetiapine is generally preferred over other antipsychotics in Parkinson disease, at the lowest effective dose.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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