Drug interactions
Quetiapine + Selpercatinib
Severity: Moderate
Quetiapine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and quetiapine carries a similar risk. Concurrent use may raise the likelihood of clinically important QT prolongation and arrhythmia.
What this interaction means in plain words
Quetiapine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor the ECG and serum electrolytes at baseline and during therapy. Replace or reduce one agent if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Quetiapine with Selpercatinib?
MediHelp rates the interaction as moderate. Quetiapine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and quetiapine carries a similar risk. Concurrent use may raise the likelihood of clinically important QT prolongation and arrhythmia.
How serious is the interaction between Quetiapine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and serum electrolytes at baseline and during therapy. Replace or reduce one agent if the QTc becomes markedly prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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