Drug interactions
Quinapril + Tizanidine
Severity: Moderate
Quinapril and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure through central alpha-2 stimulation, and quinapril, an ACE inhibitor, lowers it by reducing angiotensin II. Combined use may cause additive hypotension, particularly in volume-depleted patients or at therapy initiation.
What this interaction means in plain words
Quinapril and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering via different pathways.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Quinapril with Tizanidine?
MediHelp rates the interaction as moderate. Quinapril and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine lowers blood pressure through central alpha-2 stimulation, and quinapril, an ACE inhibitor, lowers it by reducing angiotensin II. Combined use may cause additive hypotension, particularly in volume-depleted patients or at therapy initiation.
How serious is the interaction between Quinapril and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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