Drug interactions
Quinapril + Torsemide
Severity: Moderate
Quinapril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor, especially in volume-depleted patients, can cause marked first-dose hypotension and acute deterioration of renal function. The risk is greatest at initiation or after dose increases.
What this interaction means in plain words
Quinapril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, so ACE inhibition causes exaggerated hypotension and reduced glomerular filtration.
What to do
Consider reducing or temporarily holding torsemide before starting quinapril and begin with a low quinapril dose. Monitor blood pressure, serum creatinine and potassium during the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Frequently asked questions
Can I take Quinapril with Torsemide?
MediHelp rates the interaction as moderate. Quinapril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor, especially in volume-depleted patients, can cause marked first-dose hypotension and acute deterioration of renal function. The risk is greatest at initiation or after dose increases.
How serious is the interaction between Quinapril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding torsemide before starting quinapril and begin with a low quinapril dose. Monitor blood pressure, serum creatinine and potassium during the first weeks.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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