Drug interactions
Quinidine + Rocuronium
Severity: Moderate
Quinidine and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has weak neuromuscular blocking activity and can potentiate non-depolarizing blockers such as rocuronium, with prolonged blockade or recurrent weakness after apparent recovery reported with this drug class.
What this interaction means in plain words
Quinidine and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Rocuronium belongs to Musculoskeletal.
Why it happens
Quinidine has additive curare-like effects at the neuromuscular junction, depressing postsynaptic transmission.
What to do
Monitor neuromuscular function with train-of-four and reduce rocuronium dosing as needed. Keep monitoring into the recovery period for recurrent weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Rocuronium?
MediHelp rates the interaction as moderate. Quinidine and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has weak neuromuscular blocking activity and can potentiate non-depolarizing blockers such as rocuronium, with prolonged blockade or recurrent weakness after apparent recovery reported with this drug class.
How serious is the interaction between Quinidine and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce rocuronium dosing as needed. Keep monitoring into the recovery period for recurrent weakness.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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