Drug interactions
Quinidine + Sofosbuvir-velpatasvir
Severity: Moderate
Quinidine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has a narrow therapeutic index and is metabolized by CYP3A4, and velpatasvir may modestly increase its levels. Increased quinidine concentration can prolong the QT interval and cause arrhythmias.
What this interaction means in plain words
Quinidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir weakly inhibits CYP3A4 and P-gp, which may reduce quinidine clearance.
What to do
Monitor ECG for QT prolongation and check quinidine concentrations if available. Adjust the quinidine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Quinidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has a narrow therapeutic index and is metabolized by CYP3A4, and velpatasvir may modestly increase its levels. Increased quinidine concentration can prolong the QT interval and cause arrhythmias.
How serious is the interaction between Quinidine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QT prolongation and check quinidine concentrations if available. Adjust the quinidine dose as needed.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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