Drug interactions
Quinidine + Triamterene
Severity: Moderate
Quinidine and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic cations cleared by renal tubular secretion, so quinidine may raise triamterene exposure. Triamterene can cause hyperkalemia, and altered potassium levels also affect quinidine's cardiac effects. The combination matters most in renal impairment.
What this interaction means in plain words
Quinidine and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular cationic secretion reduces triamterene clearance.
What to do
Monitor serum potassium and renal function. Check the ECG if potassium is abnormal, and reduce the triamterene dose if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Quinidine with Triamterene?
MediHelp rates the interaction as moderate. Quinidine and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are organic cations cleared by renal tubular secretion, so quinidine may raise triamterene exposure. Triamterene can cause hyperkalemia, and altered potassium levels also affect quinidine's cardiac effects. The combination matters most in renal impairment.
How serious is the interaction between Quinidine and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function. Check the ECG if potassium is abnormal, and reduce the triamterene dose if hyperkalemia develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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