Drug interactions
Quinidine + Vincristine
Severity: Moderate
Quinidine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-gp and may raise vincristine exposure, which could worsen peripheral neuropathy, constipation and other neurotoxicity. The evidence is mainly mechanistic and preclinical.
What this interaction means in plain words
Quinidine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vincristine belongs to Oncology.
Why it happens
Quinidine inhibits P-gp-mediated efflux of vincristine, increasing its exposure.
What to do
Monitor for neurotoxicity such as neuropathy and ileus, and reduce the vincristine dose if it occurs. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Quinidine with Vincristine?
MediHelp rates the interaction as moderate. Quinidine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-gp and may raise vincristine exposure, which could worsen peripheral neuropathy, constipation and other neurotoxicity. The evidence is mainly mechanistic and preclinical.
How serious is the interaction between Quinidine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity such as neuropathy and ileus, and reduce the vincristine dose if it occurs. Consider an alternative antiarrhythmic.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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