Drug interactions
Quinine + Quizartinib
Severity: Major
Quinine and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib carries a labeled risk of QT prolongation, torsades de pointes and cardiac arrest, and quinine adds its own QT-prolonging effect. The combination may substantially increase the likelihood of a dangerous arrhythmia.
What this interaction means in plain words
Quinine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Quizartinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible; if quinine is essential, monitor ECG more frequently and keep potassium and magnesium within normal range. Follow quizartinib labeling for dose reduction or interruption if the QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quinine with Quizartinib?
MediHelp rates the interaction as major. Quinine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib carries a labeled risk of QT prolongation, torsades de pointes and cardiac arrest, and quinine adds its own QT-prolonging effect. The combination may substantially increase the likelihood of a dangerous arrhythmia.
How serious is the interaction between Quinine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if quinine is essential, monitor ECG more frequently and keep potassium and magnesium within normal range. Follow quizartinib labeling for dose reduction or interruption if the QTc lengthens.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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