Drug interactions
Quinine + Saxagliptin-metformin
Severity: Moderate
Quinine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and quinine are both cationic drugs handled by renal tubular secretion, so metformin may modestly increase quinine levels. Quinine itself can also cause hypoglycemia, which is relevant in patients treated for diabetes.
What this interaction means in plain words
Quinine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transporters, plus quinine-induced stimulation of insulin secretion.
What to do
Monitor blood glucose for hypoglycemia and watch for quinine toxicity such as cinchonism or QT effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Quinine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metformin and quinine are both cationic drugs handled by renal tubular secretion, so metformin may modestly increase quinine levels. Quinine itself can also cause hypoglycemia, which is relevant in patients treated for diabetes.
How serious is the interaction between Quinine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose for hypoglycemia and watch for quinine toxicity such as cinchonism or QT effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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