Drug interactions
Quinine + Selexipag
Severity: Minor
Quinine and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine may inhibit CYP2C8 and thereby raise exposure to the active metabolite of selexipag, though the effect is not well characterized. Increased exposure could cause more headache, diarrhea, nausea and jaw pain.
What this interaction means in plain words
Quinine and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quinine belongs to Anti Parasitic; Selexipag belongs to Cardiovascular.
Why it happens
Possible CYP2C8 inhibition reducing hydrolysis-derived metabolite clearance of selexipag; effect is predicted rather than established.
What to do
Monitor for prostacyclin-type adverse effects and consider reducing selexipag frequency if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Quinine with Selexipag?
MediHelp rates the interaction as minor. Quinine and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine may inhibit CYP2C8 and thereby raise exposure to the active metabolite of selexipag, though the effect is not well characterized. Increased exposure could cause more headache, diarrhea, nausea and jaw pain.
How serious is the interaction between Quinine and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-type adverse effects and consider reducing selexipag frequency if they become troublesome.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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