Drug interactions
Quinine + Topotecan
Severity: Moderate
Quinine and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein and may increase topotecan absorption and exposure, especially for oral topotecan. This could worsen myelosuppression.
What this interaction means in plain words
Quinine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Topotecan belongs to Oncology.
Why it happens
P-glycoprotein inhibition by quinine reduces topotecan efflux.
What to do
Avoid with oral topotecan. With intravenous topotecan, monitor blood counts closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Quinine with Topotecan?
MediHelp rates the interaction as moderate. Quinine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits P-glycoprotein and may increase topotecan absorption and exposure, especially for oral topotecan. This could worsen myelosuppression.
How serious is the interaction between Quinine and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With intravenous topotecan, monitor blood counts closely.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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