Drug interactions
Quinine + Vardenafil
Severity: Major
Quinine and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is a known QT-prolonging drug that can cause torsades de pointes, and vardenafil may add a small effect. The combination may increase arrhythmia risk, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Quinine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid vardenafil during quinine treatment where possible. If both are needed, correct potassium and magnesium and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Vardenafil?
MediHelp rates the interaction as major. Quinine and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinine is a known QT-prolonging drug that can cause torsades de pointes, and vardenafil may add a small effect. The combination may increase arrhythmia risk, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Quinine and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vardenafil during quinine treatment where possible. If both are needed, correct potassium and magnesium and monitor the ECG.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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