Drug interactions
Quinine + Ziprasidone
Severity: Contraindicated
Quinine and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval and ziprasidone is labeled to be avoided with other QT-prolonging agents. Combined use may precipitate torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Quinine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Quinine belongs to Anti Parasitic; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation via cardiac potassium channel blockade.
What to do
Avoid using together; choose an alternative antimalarial or antipsychotic. If unavoidable, monitor the ECG and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Quinine with Ziprasidone?
MediHelp rates the interaction as contraindicated. Quinine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval and ziprasidone is labeled to be avoided with other QT-prolonging agents. Combined use may precipitate torsades de pointes and sudden cardiac death.
How serious is the interaction between Quinine and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together; choose an alternative antimalarial or antipsychotic. If unavoidable, monitor the ECG and correct electrolytes.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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