Drug interactions
Quinupristin / dalfopristin + Rimegepant
Severity: Moderate
Quinupristin / dalfopristin and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase rimegepant exposure. The magnitude is not well characterized but could increase adverse effects.
What this interaction means in plain words
Quinupristin / dalfopristin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by quinupristin/dalfopristin.
What to do
For acute treatment, avoid repeating rimegepant within 48 hours. No adjustment is needed for preventive dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Quinupristin / dalfopristin with Rimegepant?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase rimegepant exposure. The magnitude is not well characterized but could increase adverse effects.
How serious is the interaction between Quinupristin / dalfopristin and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute treatment, avoid repeating rimegepant within 48 hours. No adjustment is needed for preventive dosing.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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