Drug interactions
Quinupristin / dalfopristin + Saxagliptin
Severity: Minor
Quinupristin / dalfopristin and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise saxagliptin levels while reducing formation of its active metabolite. Because saxagliptin has a wide margin of safety, the clinical effect is expected to be limited.
What this interaction means in plain words
Quinupristin / dalfopristin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by quinupristin/dalfopristin reduces saxagliptin metabolism.
What to do
No routine dose change is needed; monitor glucose, and consider a lower saxagliptin dose only if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Quinupristin / dalfopristin with Saxagliptin?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and may raise saxagliptin levels while reducing formation of its active metabolite. Because saxagliptin has a wide margin of safety, the clinical effect is expected to be limited.
How serious is the interaction between Quinupristin / dalfopristin and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glucose, and consider a lower saxagliptin dose only if adverse effects appear.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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