Drug interactions
Quinupristin / dalfopristin + Solifenacin
Severity: Moderate
Quinupristin / dalfopristin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise solifenacin concentrations. This could increase anticholinergic adverse effects and QT risk.
What this interaction means in plain words
Quinupristin / dalfopristin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated solifenacin metabolism.
What to do
Monitor for anticholinergic effects and QT changes during the antibiotic course. Limit solifenacin to 5 mg daily if the interaction is considered significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Quinupristin / dalfopristin with Solifenacin?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise solifenacin concentrations. This could increase anticholinergic adverse effects and QT risk.
How serious is the interaction between Quinupristin / dalfopristin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and QT changes during the antibiotic course. Limit solifenacin to 5 mg daily if the interaction is considered significant.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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