Drug interactions
Quizartinib + Sorafenib
Severity: Major
Quizartinib and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and sorafenib has additional QT-prolonging potential. Together they may raise the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Quizartinib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quizartinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG more frequently and keep potassium and magnesium within normal range. Reduce the quizartinib dose or interrupt treatment if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sorafenib
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Quizartinib with Sorafenib?
MediHelp rates the interaction as major. Quizartinib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and sorafenib has additional QT-prolonging potential. Together they may raise the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Quizartinib and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more frequently and keep potassium and magnesium within normal range. Reduce the quizartinib dose or interrupt treatment if QTc becomes markedly prolonged.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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